Paclitaxel resistant cell line

Author: qmcf

August undefined, 2024

WebPaclitaxel is known as a chemotherapy drug that can suppress the proliferation of cancer cells by inducing cell cycle arrest and induction of mitotic catastrophe. However, today, it is well... WebThe SKOV-3 ovarian serous carcinoma cell line, which has inducible expression of dominant negative Nac1, was used to determine the paclitaxel treatment associated …

xCT inhibitor sulfasalazine depletes paclitaxel‑resistant tumor cells ...

WebJan 13, 2024 · Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important … WebOct 21, 2024 · Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein … molly mcbride gyn

Erlotinib overcomes paclitaxel-resistant cancer stem cells by

WebApr 8, 2024 · The paclitaxel-resistant cells were cultured in the medium of RPMI-1640 with 10% fetal bovine serum in an incubator containing 5% CO 2 at 37 °C. MTT assay Exponentially growing A549/PTX cells were seeded in 96-well plates (5000 cells/well) and cultured overnight. WebThe SKOV-3 ovarian serous carcinoma cell line, which has inducible expression of dominant negative Nac1, was used to determine the paclitaxel treatment associated changes in the presence and absence of functional Nac1. ... Go analysis of the protein changes identified upon paclitaxel resistance revealed that cell component enrichment … molly mcbeath falkirk

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Penfluridol overcomes paclitaxel resistance in metastatic breast …

WebDec 29, 2024 · Material and Methods: Hs578T cancer cell lines were used to develop paclitaxel-resistant (Hs578T-PR) cells, via repeated exposure to increasing concentrations of paclitaxel in a... WebApr 10, 2024 · Cytotoxic Effect of CUR and PTX. An MTT assay assessed the cytotoxic effects of CUR and PTX compounds after 72 h of incubation, as shown in Fig. 1 and Table 1.The results show that CUR and PTX significantly inhibited TSCCF cell viability in a dose- and time-dependent manner with IC 50 of 13.85 and 8.17 µg mL −1, respectively.While … molly mcauliffeWebAug 18, 2024 · Overexpression of ATP-binding cassette drug efflux transporters (ABC transporters, such as ABCB1 or MDR1) on the plasma membrane of cancer cell lines, isolated as paclitaxel- or olaparib-resistant cells, has been regarded as a mechanism of drug resistance toward relatively lipophilic anti-cancer drugs, such as doxorubicin, … molly mcawesome

"WebSep 24, 2024 · The SKOV3/MRP7 cell line was resistant to multiple anticancer drugs including paclitaxel, docetaxel, vincristine and vinorelbine with a maximum of 8-fold resistance. Biological function of MRP7 protein was further determined by efflux-accumulation assays. " - Paclitaxel resistant cell line

Paclitaxel resistant cell line

WebSK-OV-3 cells are resistant to tumor necrosis factor and to several cytotoxic drugs including diphtheria toxin, cis-platinum and adriamycin. Handling information Unpacking and storage instructions Check all containers for leakage or breakage. WebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed …

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WebEpithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related death. The high mortality and morbidity associated with EOC are mostly due to late diagnosis … WebIn addition, paclitaxel-resistant cell lines of HCC cells were established, whose activity was assessed by CCK-8 assay, among which the invasion ability was assessed by …

WebTo better understand biological mechanisms at the basis of paclitaxel resistance, a comparative proteomic approach based on DIGE coupled with mass spectrometry … WebPaclitaxel is known as a chemotherapy drug that can suppress the proliferation of cancer cells by inducing cell cycle arrest and induction of mitotic catastrophe. However, today, it is well...

WebNov 20, 2024 · Multi drug resistance of cancer cells during chemotherapy it has been associated with a different type of mechanisms that are including enhanced efflux of drugs, genetic factors (gene mutations, amplifications, and epigenetic alterations), growth factors, increased DNA repair capacity, and also elevated metabolism of xenobiotics. WebMar 11, 2015 · Breast cancer is one of the most prevalent types of malignant tumor. Paclitaxel is widely used in the treatment of breast cancer; however, the major problem contributing to the failure of chemotherapy in breast cancer is the development of drug resistance. Therefore, it is necessary to identify novel therapeutic targets and reversal …

WebNov 26, 2024 · Paclitaxel is one of the first-line chemotherapeutic agents for recurrent or metastatic cervical cancer 16. CSCs resistance to paclitaxel has been reported. For instance, ovarian CSCs were...

WebMar 25, 2024 · In the present study, we have developed paclitaxel resistant cells by continuous exposure to paclitaxel for several months. The cells were analyzed for … hyundai scheduled serviceWebMethods: Using the dose calculated from clinical chemotherapy, we established a TAX-resistant human ovarian carcinoma cell line OC3/TAX300 by intermissive and repeated … molly mcawesome instagramWebWe conducted a phase II trial to evaluate the safety and efficacy of weekly paclitaxel in patients with resistant or relapsed non-small cell lung cancer (NSCLC) treated with docetaxel and carboplatin. Thirty-two NSCLC patients at a median age of 58.0 years (range 33-75) were enrolled. The Eastern Co … hyundai scholarship programWebDec 8, 2024 · The human non-small cell lung cancer cell line A549 and the paclitaxel-resistant cell line A549/Taxol were donated by Prof. Yang from Qiqihar Medical … molly mcbride obituaryWebJun 18, 2024 · Paclitaxel (PTX), the most widely used taxane, has become the first-line drug against OC. The molecular mechanism of PTX resistance is different from that of platinum-based agents and is... molly mcbride obgyn nycWebThis study was conducted to establish paclitaxel-resistant breast cancer cell line and nude mice models to explore underlying mechanisms of MDR. Methods: The breast cancer … molly mcbride live 5 newsWebAn understanding of the mechanisms of intrinsic or acquired resistance of cancer cells to paclitaxel can result in (1) design of better therapeutic modalities (drug combinations, … hyundai school trips