WebMar 21, 2024 · HIV-1 Vpu-induced cleavage of IRF3 is largely dependent on the ability of Vpu to interact with beta-TrCP, and mutation of the Vpu phosphorylation sites Ser52 and … WebApr 12, 2024 · It was found that TMEM173 N153S mutation triggers lung inflammation independently of cGAS and IRF3, which mainly increases the phosphorylation of STAT1 in T lymphocytes, thereby increasing the transcription of ISG such as Cxcl10 and leading to autoimmune disease (96–98, 101, 102).
IRF3 interferon regulatory factor 3 [Homo sapiens (human
WebFeb 3, 2024 · By searching an EST database for sequences similar to those of IRF1 and IRF2, Au et al. (1995)identified IRF3, a novel member of the IRF family. The IRF3 gene is present … WebSep 26, 2024 · Given that IRF3 does not play a role in the disease in mice, it seems plausible that STING mutations in humans also cause disease via other mechanisms and that up … pomerene family health
Functional IRF3 deficiency in a patient with herpes …
WebMar 21, 2024 · Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2024] GeneCards Summary for IRF3 Gene IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute ... WebMar 10, 2011 · In murine embryonic fibroblasts, IFN-β induction is mediated by the activation of both IRF3 and IRF7. 16, 17 In contrast, induction of IFN-β in murine plasmacytoid dendritic cells occurs after CpG recognition by Toll-like receptor 9 and is entirely dependent on IRF7, 18 whereas in murine macrophages transcription of IFN- β is dependent on IRF3 … WebApr 25, 2003 · Interferon regulatory factor 3 (IRF3) is activated in response to various environmental stresses including viral infection and DNA-damaging agents. However, the biological function of IRF3 in cell growth is not well understood. We demonstrated that IRF3 markedly inhibited growth and colony formation of cells. shannon property group